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Final Results from the ILLUMINATE Trial
Adapted from Barter et al. N Engl J Med 2007;357:2109-2122
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Featured Article
Ranolazine Reduces Hemoglobin A1c in Diabetic Patients

This finding from the MERLIN-TIMI 36 study was presented by Dr. David Morrow at the American Heart Association Scientific Sessions 2007. In MERLIN-TIMI 36, investigators randomized diabetic and non-diabetic patients with unstable angina or non-ST-segment-elevation myocardial infarction (NSTEMI) to intravenous ranolazine followed by 1,000 mg bid oral administration or placebo
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Editor-in-Chief
S.P. Marso (US)

Editorial Board
P. Barter (AUS)
D.S.H. Bell (US)
J. Betteridge (UK)
J. Chapman (FRA)
S. DelPrato (ITA)
M.E. Farkouh (US)
A. Felton (UK)
P. Grant (UK)
M. Kirby (UK)
D.K. McGuire (US)
J. Nolan (IRL)
R. Nesto (US)
C. Patterson (US)
C. Reasner (US)
D. Tschope (DEU)

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Hyperglycemia Lectures Part IV:
Clinical Trials of ACS

In Part IV of a series of expert lectures on hyperglycemia in the acute care setting, Dr. Nicholas Emanuele, Director of Endocrinology at the Loyola University Chicago School of Medicine, discusses the major clinical trials on hyperglycemia in the setting of acute coronary syndromes, specifically with respect to the effect of intensive insulin therapy to achieve tight glycemic control on mortality in critically ill patients. The discussion begins with an overview of early prospective trials of intensive insulin therapy, including DIGAMI and the Leuven SICU study, to contemporary cohorts such as DIGAMI 2, CREATE-ECLA, and HI-5.

 

Download Lecture
Download Part I: Intensive Glucose Control in ACS
Download Part II: Vascular Biology of Hyperglycemia
Download Part III: Prevalence During ACS
 

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Latest News

ADA 2008: Multiple Risk Factors May Negate Benefits of Aggressive Glucose Control
June 10, 2008 - Diabetic patients with multiple comorbidities may benefit less from aggressive management of risk factors than patients with fewer comorbidities More Info

ADA 2008: VA-Diabetes Results Show No Intensive Glucose Control Benefits
June 10, 2008 - In the second trial at the American Diabetes Association Scientific Sessions 2008 of intensive glucose control in a type 2 diabetic population, investigators with the VA (Veteran’s Affairs) Diabetes trial More Info

ADA 2008: Nurse-Directed Care Improves Outcome Measures in Diabetic Patients
June 10, 2008 - Placement of a nurse specifically trained to treat diabetic patients in a primary care clinic improves guideline-based measures including hemoglobin A1c, LDL cholesterol, and blood pressure More Info

ADA 2008: Screening for Coronary Artery Disease Does Not Benefit Asymptomatic Type 2 Diabetic Patien
June 10, 2008 - Results from 5 years of follow-up on patients participating in the DIAD indicate that screening for CAD) does not significantly improve outcomes in type 2 diabetic patients. More Info

ADA 2008: Investigators Predict Shortage of Physicians Who Will Treat Diabetic Patients
June 10, 2008 - A survey of current medical students in the United States found that very few plan to specialize in endocrinology with or without an emphasis on treating diabetes More Info

ADA 2008: Final Results from the ADVANCE Trial
June 9, 2008 - The first of three trials evaluating the efficacy of intensive glucose reduction in type 2 diabetic patients was presented at the American Diabetes Association Scientific Sessions 2008 More Info

AAN 2008: Lacosamide Improves Diabetic Neuropathic Pain
April 21, 2008 - Lacosamide seems to be an effective and well tolerated treatment for neuropathic pain secondary to diabetes, researchers announced at the 60th Annual AAN Meeting More Info

ACC 2008: STRADIVARIUS Provides More Rimonabant Findings
April 3, 2008 - Results from the STRADIVARIUS study show that the jury is still out on whether or not rimonabant (Acomplia, Sanofi-Aventis) slows progression of coronary heart disease More Info

ACC 2008: Results from the PERISCOPE Trial
April 1, 2008 - Pioglitazone (Actos, Takeda) prevents progression of atherosclerosis and reduces cardiovascular risk factors compared to glimepiride (Amaryl, sanofi-aventis) More Info

Slideset: Diabetes Costs in the United States for Year 2007
February 20, 2008 - In an updated analysis from the American Diabetes Association, investigators estimate the total economic burden associated with diabetes mellitus in the year 2007 was $156 billion More Info

NHLBI Stops Intensive Glucose Control in the ACCORD Trial
February 7, 2008 - The National Heart Lung & Blood Institute (NHLBI) announced that it has stopped administering intensive blood glucose treatment to patients participating in the ACCORD trial More Info

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